The deletion of ZNF2 locks cells in the yeast phase and enhances virulence while the overexpression of ZNF2 leads to filamentation in vivo and abolishes cryptococcal virulence in the clinical isolate H99 background and significantly attenuates the virulence in the XL280 background in a mouse model of cryptococcosis [7], [28]. This evidence concerns the gene ZNF2 and cryptococcosis.