In this study, we demonstrated that MLN8237 not only significantly increased SA- ß-gal activity in GIST cells (Figure 7A and 7B), but also induced expression of senescence biomarkers such as DEC1, DcR2, and IL-6 (Figure 7C, 7D, and 7E) [25, 26]. This evidence concerns the gene IL6 and gastrointestinal stromal tumor.