In the same study, the treatment of low-grade RT4 human urothelial cell carcinoma with capsaicin at 100 μM dose induced a TRPV1-dependent G0/G1 cell cycle arrest and apoptosis, effect that was seen associated with the transcription of proapoptotic genes including Fas/CD95, Bcl-2, and caspases, and the activation of the DNA damage response pathway [74]. This evidence concerns the gene TRPV1 and transitional cell carcinoma.