More recently, Amantini et al. displayed a marked decrease or absence of TRPV1 labelling in urothelial cancer specimens proportionally to differentiation levels decrease after a quantitative real-time PCR and that TRPV1 mRNA level was highly expressed in low-grade cancers, whereas its expression, confirming the previous results, was reduced in high-grade tumors or in advanced stage invasive pathologies. This evidence concerns the gene TRPV1 and cancer.