On the other hand, attention has to be paid to the Capsaicin property to exhibit tumor-promoting effects, in a receptor-dependent manner, in particular in cancer strain cells lacking TRPV1 receptor, where the transfection with the TRPV1 cDNA leads to an increase in capsaicin-mediated calcium level, growth inhibition, apoptosis, and capsaicin-induced migration regression, suggesting that the TRPV1 plays an inhibitory role in urothelial cancer invasion and metastasis [75]. The gene discussed is TRPV1; the disease is cancer.