The in vivo and in vitro cancer growth and progression inhibition, the induction of apoptosis, and the antimigration activity of capsaicin in tumor of other tissues, such as gastric cancer and glioma, and the studies of Lazzeri and Amantini's groups suggest a theoretical role of targeting the TRPV1 for clinical management of urothelial cancer. This evidence concerns the gene TRPV1 and cancer.