Variations of genes involved in lipoprotein and lipid metabolism are playing an important role in the susceptibility of CHD [6]. LDLR gene mutations can lead to deficiency or abnormality of LDLR in the cell membrane surface and thus disrupt lipid metabolism [4]. LDLR gene mutations are known to cause familial hypercholesterolemia (FH) [2] that is an important risk factor of CHD and other atherosclerotic diseases [7]. This evidence concerns the gene LDLR and coronary artery disorder.