In order to explore the mechanism by which multidietary nutrients putatively protect against AD, Jansen and colleagues investigated the effects on, among others, neural plasticity markers and associated behavior in apoE4-carrier and apoE knockout mice of a diet containing DHA, EPA, phospholipids, uridine monophosphate (UMP), choline, B vitamins, and antioxidants [213]. The gene discussed is APOE; the disease is Alzheimer disease.