BDNF and Anxiety: Using a similar approach of switching rats from a PUFA-enriched or deficient diet to a western-like diet (WD) with higher percentage of fat and carbohydrates during the period of brain maturation, Tyagi et al. report increased anxiety-like behavior and decreased expression of the anxiety-related NPY-1 receptor, along with disruption of BDNF signaling in the frontal cortex of rats after mild traumatic brain injury (mTBI) [188].