For example, Dong and coworkers additionally report that 12-week curcumin treatment of aged rats resulted in markedly differential expression of genes thought to participate in both the AD neurodegenerative process and synaptic plasticity [147], such as the Cav1 gene implicated in alterations of cholesterol distribution in the AD brain [156], spatial memory formation [157], and age-related working memory decline [158]. Here, CAV1 is linked to Alzheimer disease.