BDNF and Cognitive impairment: Chronic administration of resveratrol was able to prevent a wide range of detrimental effects on cognition induced by the classic unpredictable chronic mild stress model of depression [136], including reduction in serum corticosterone levels, increased levels of BDNF, phosphorylated extracellular signal-regulated kinase (pERK) and pCREB in the prefrontal cortex and hippocampus, and prevention of cognitive deficits [137].