NFASC and neurofibromatosis type 1: Neurofibromatosis type 1 (NF 1), or von Recklinghausen's disease, is an autosomal dominant disorder clinically diagnosed by six or more cafe au lait macules; two or more cutaneous/subcutaneous neurofibromas or a single plexiform neurofibroma; axillary or inguinal freckling; optic nerve glioma; two or more Lisch nodules (iris hamartomas); dysplasia of long bones or pseudarthrosis; and a first degree relative with NF1 [28, 82].