TLR4 and Obesity: Overall, adiponectin promotes anti-inflammation through inhibiting proinflammatory response, polarizing macrophages (from M1 to M2), and T helper cells (from Th1/17 to Th2/Treg), inhibiting TLR4-mediated NF-κB activation, and protecting endothelium, suggesting that obesity may prime lung toward proinflammatory condition and more susceptible for injury due to hypoadiponectinemia, at least partially.