Yet, based on what we reviewed here, adiponectin showed a strong anti-inflammatory effect in obesity, through its activation of AMPK and stimulation of mitochondrial biogenesis, as well as its inhibition of NF-κB signaling pathways and oxidative stress; we believe that adiponectin and adiponectin receptor agonist as well as AMPK activator would greatly benefit patients from a variety of aspects, including lung injury in obesity. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.