Overall, adiponectin promotes anti-inflammation through inhibiting proinflammatory response, polarizing macrophages (from M1 to M2), and T helper cells (from Th1/17 to Th2/Treg), inhibiting TLR4-mediated NF-κB activation, and protecting endothelium, suggesting that obesity may prime lung toward proinflammatory condition and more susceptible for injury due to hypoadiponectinemia, at least partially. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.