The majority of the evidence supported that adiponectin, omentin, and SFRP5 are anti-inflammatory, the good, and are decreased in obesity, which is associated with increased systemic inflammation, indicated by increased circulating TNFα, C reactive protein (CRP), IL-6, and other proinflammatory cytokines/chemokines [17, 18]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.