For instance, in transgenic mice expressing mutated superoxide dismutase 1 (SOD1), an animal model of amyotrophic lateral sclerosis (ALS; a motor neuron degenerative disease), transplantation of GFP-expressing wild-type BM cells led to GFP-positive neurons (not exclusively Purkinje cells), including some containing two nuclei, detected in both the brain and spinal cord [9]. Here, SOD1 is linked to amyotrophic lateral sclerosis.