This revealed that some cancer clones were able to form robust lung metastasis even in the presence of RBM47 (Figure 3A, Figure 3—figure supplement 1A), but that many of the metastases formed after the inoculation of wild type RBM47-expressing cells had avoided or suppressed the expression of RBM47 (Figure 3B, Figure 3A—figure supplement 1A). Here, RBM47 is linked to cancer.