For example, DKK1 (Bafico et al., 2004; Cowling et al., 2007; Mikheev et al., 2008), HTATIP2 (Zhao et al., 2007), HBP1 (Paulson et al., 2007; Li et al., 2011), MXI1 (Lahoz et al., 1994) and CASP7 (Hudson et al., 2013), all bound by RBM47 and upregulated upon RBM47 reintroduction, have known tumor suppressive functions. This evidence concerns the gene RBM47 and neoplasm.