For example, DKK1 (Bafico et al., 2004; Cowling et al., 2007; Mikheev et al., 2008), HTATIP2 (Zhao et al., 2007), HBP1 (Paulson et al., 2007; Li et al., 2011), MXI1 (Lahoz et al., 1994) and CASP7 (Hudson et al., 2013), all bound by RBM47 and upregulated upon RBM47 reintroduction, have known tumor suppressive functions. The gene discussed is DKK1; the disease is neoplasm.