In amyotrophic lateral sclerosis, endoplasmic reticulum stress markers including BiP and CHOP are elevated in motor neurons of SOD1G93A mice that model the disease (Saxena et al., 2009), as well as in spinal cord autopsy tissue of patients with the disease (Atkin et al., 2008). The gene discussed is DDIT3; the disease is amyotrophic lateral sclerosis.