Indeed, NAHR between inverted LCRs present within the IDS gene and its telomeric pseudogene IDSP1 is responsible for approximately 13% of mucopolysaccharidosis type II (Hunter syndrome; MIM# 309900) cases [34] and inversion between inverted-oriented LCRs disrupting the factor VIII gene (F8) accounts for >45% of severe hemophilia A (MIM# 306700) cases. Here, F8 is linked to hemophilia A.