Moreover, the anti-tumor activity of IFN-α2a-NGR at MD was similar or higher than that of IFN-α2a at HD, and the anti-tumor activity of IFN-α2a-NGR at LD was similar or higher than that of IFN-α2a at MD, suggesting that IFN-α2a-NGR was more effective in reducing tumor size in vivo. Here, IFNA2 is linked to neoplasm.