Since SIVrcm from red-capped mangabeys often uses CCR2 as a coreceptor due to the absence of CCR5 [29]–[31] and since SIVsmm from sooty mangabeys can also use a coreceptor other than CCR5 to mediate infection in vivo[32], [33], it is possible that the unique variants like ZP6248 may become prevalent in humans, especially in the face of use of CCR5 antagonists, which may lead to the selection and spread of viruses that are able to establish infection without using CCR5. Here, CCR2 is linked to infection.