GNAS mutations have also been previously reported in IPMN [11], [12] cases that had pancreatic cysts [10], [12], [16] with a detection rate of 41–66% from resected tissues, pancreatic cyst fluids, or secretin-stimulated pancreatic juice collected from the duodenum. This evidence concerns the gene GNAS and pancreatic intraductal papillary-mucinous neoplasm.