INS and Insulin resistance: Affuso 2010[24] indicated that there was no significant change in insulin level in the intervention group [from (63.2±36.1) pmol/l to (60.5±39.6) pmol/l] and the placebo group [from (59.7±27.1) pmol/l to (56.3±27.1) pmol/l], and in a subgroup of 11 subjects with insulin resistance (baseline HOMA index>2.6), HOMA index [from (3.3±0.4) to (2.5±1.3)] was significantly reduced, while the QUICKI index [from (0.32±0.005) to (0.34±0.02)] and McAuley index[from (5.73±1) to (6.9±1)] were significantly increased, which indicated enhanced insulin sensitivity.