AKT1 and cancer: In particular, recent studies have verified the over-expression of CXCL16 and/or CXCR6 in several types of human cancers and CXCL16 could stimulate the growth, migration, invasion and activation of AKT signaling pathway of cancer cells via its’ receptor CXCR6 in vitro[15], [16], [17], [18].