For example, in prostate cancer, inflammatory cytokines derived from the adjacent infiltrating CXCR6-positive T cells stimulate the production of CXCL16 by cancer cells and CXCL16 enhance the growth of CXCR6-expressing cancers and primary T cells, indicating that CXCL16 and CXCR6 mediate pro-tumorigenic effects between tumorassociated leukocytes and cancer cells in an specific inflammatory milieu [17]. The gene discussed is CXCL16; the disease is Familial prostate cancer.