However, the neutralizing antibody to CXCL16 or CXCR6 protein down-regulation only partially blocked the increased invasion of A549, 95D and H292 induced by their respective CM, which suggests that besides of CXCL16-CXCR6, there are others signals and molecules regulating the invasion of lung cancer cells. This evidence concerns the gene CXCL16 and lung cancer.