SIRT1 and cancer: For example, several reports have demonstrated SIRT1 upregulation in human cancers including, invasive human ductal carcinoma [1], malignant human breast carcinoma [2], hepatocellular carcinoma [3], diffuse B-cell lymphoma [4], gastric carcinoma [5], and colorectal cancer with microsatellite instability and CpG island methylator phenotype [6].