For example, SIRT1 has been shown to participate in silencing tumor suppressor genes [9], [10], stabilization of Dishevelled and β-catenin [11], promotion of cell migration [11]–[13], aromatase expression [1], estrogen receptor signaling [14] and chemoresistance to conventional chemotherapeutic agents [15], [16]. The gene discussed is SIRT1; the disease is neoplasm.