Waist circumference, HOMA2-IR, triglyceride, HDL cholesterol, and HS-CRP significantly correlated with T-LTPA in both non-obese and obese participants after multivariate adjustments for age, sex, duration of diabetes, current smoking, current drinking, energy intake, cardiovascular diseases, depressive symptoms, and treatment of diabetes. The gene discussed is CRP; the disease is diabetes mellitus.