In the present study, the interaction between T-LTPA and the percentage of higher-intensity LTPA per T-LTPA was significant on HbA1c and HOMA2-IR, suggesting the role of the intensity of PA in the regulation of glycemia and insulin action, at least in Japanese type 2 diabetic patients who are leaner than Western patients. The gene discussed is INS; the disease is type 2 diabetes mellitus.