TNPO1 and intrahepatic cholangiocarcinoma: Signaling pathway enrichment analysis of differentially expressed genes of CNV-ICC-TRN between two clusters () suggested that these two classes had different malignancy features: highly expressed genes in cluster I were enriched to cell adhesion related pathways, such as focal adhesion and tight junction; highly expressed genes in cluster P were enriched to oncogenic signaling pathways such as MAPK signaling, Wnt signaling pathway (Table S7).