We first constructed TRN of ICC (ICC-TRN) using forward-and-reverse combined engineering method, and then extracted modules from ICC-TRN to form CNV-ICC-TRN according to the following selection standards: 1) the selected modules should have biological significance; 2) the selected modules are regulated by CNV-TF, or enriched by CNV-genes. This evidence concerns the gene TF and intrahepatic cholangiocarcinoma.