In this context, visceral fat seems to play a role in NAFLD progression due to its ability to actively secret a multitude of different adipokines such as tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), macrophage chemoattractant protein (MCP)-1 and resistin, which promote insulin resistance and type 2 diabetes mellitus (TD2M) [79,80,81]. This evidence concerns the gene TNF and Insulin resistance.