Though ALT-803 lost its antimyeloma activity in tumor-bearing IFN-γ knockout mice, it was able to retain its ability to promote CD8(+)CD44(high) memory T-cell proliferation, indicating that ALT-803-mediated stimulation of CD8(+)CD44(high) memory T-cells is IFN-γ-independent [23]. This evidence concerns the gene IFNG and neoplasm.