In conclusion, our data show that mice with a global Irp2 deficiency recapitulate the main features of other Irp2 deficient mouse models such as microcytic anemia, erythropoietic protoporphyria, altered body iron distribution and altered expression of ferritin and TfR1 in tissues. The gene discussed is TFRC; the disease is erythropoietic protoporphyria.