However, two NBIA diseases, hereditary ferritinopathy and aceruloplasminemia, caused by mutations in the ferritin-L subunit gene (FTL) [9] and in the ceruloplasmin (CP) gene [10], respectively, suggest that abnormal iron metabolism is the pathologic event leading to neurodegeneration in these disorders. The gene discussed is CP; the disease is neuroferritinopathy.