In order to investigate glucagon effects in cardiac anaphylaxis, in this study we estimated the influence of acute glucagon application on 3H-histamine uptake, during a single 3H-histamine passage through the coronary circulation, before and during the anaphylaxis, as well as the influence of glucagon on level of histamine, NO, and oxidative stress mediators during anaphylaxis. The gene discussed is GCG; the disease is anaphylaxis.