Therefore, in this study, we put the three genes together, along with JAK2V617F, to determine their mutational status in a series of well-defined adult Chinese patients with MPN and explored their clinical significance; also, the association between JAK2V617F mutation and DNMT3A, NPM1, or FLT3-ITD mutation was also investigated. This evidence concerns the gene DNMT3A and myeloproliferative neoplasm.