Considering the causative role of oxidative stress and the protective effect of sufficient autophagy activation in Dox-induced cardiotoxicity as well as the Nrf2-mediated antioxidant defense and sufficient activation of autophagy, it is conceivable that Nrf2 is a negative regulator of Dox-induced cardiomyopathy. The gene discussed is NFE2L2; the disease is cardiomyopathy.