The finding in our study that nonobese PCOS patients have increased adrenocortical production with normal suppressible cortisol production after low dose of DEX, and a demonstration of a possible influence of LH in adrenal steroidogenesis as described before suggests that LH might influence adrenocortical production in nonobese PCOS women, presumably increasing the adrenocortical response to ACTH. The gene discussed is POMC; the disease is polycystic ovary syndrome.