Some studies suggest that insulin is a negative modulator of adrenal androgen metabolism [37, 38], although some studies using insulin sensitizers in PCOS women showed a decrease of adrenal androgens after their administration [9, 39]; however this event could be consequent to decreases in LH levels that also occurs after metformin administration to these women [39]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.