COL4A1 and cataract: Pathologies in Col4a1 mutants include iris defects, corneal opacities, vacuolar cataracts and significant iris/corneal adhesions (40), disorganization of the lens epithelial layer together with vacuoles in the underlying secondary fiber cell region and corneal-lens adhesion (41) or corneal opacity, enlarged and torturous iris vasculature, cataracts and iridocorneal adhesion (42,43).