SERPINE1 and metabolic syndrome: Metabolic syndrome in humans is characterized by abdominal obesity, hypertension, dyslipidemia (hypertriglyceridemia, decreased HDL, and cholesterolemia), insulin resistance, increased oxidative burst, vascular dysfunction, increased coagulability (increased fibrinogen and tissue PAI1), and inflammation of adipose tissue (44, 45, 46, 47, 48, 49, 50, 51).