Comparison of HLA-DRB1*12 allele frequencies between myositis patients with and without ILD showed a similar trend of being higher among those with ILD than among those without, although the difference between the two groups was not statistically significant (p = 0.35; OR = 1.59; 95% CI: 0.63–4.00). This evidence concerns the gene HLA-DRB1 and interstitial lung disease.