Encouragingly, recent molecular and proteomic analyses of autopsy specimens have identified key genetic alterations in DIPG, including amplifications in genes encoding receptor tyrosine kinases (PDGFRA, MET)[2], PDGFRA mutations[3], as well as distinct DIPG subgroups based on Hedgehog (SHH) and MYCN pathway activation[4]. The gene discussed is PDGFRA; the disease is diffuse intrinsic pontine glioma.