This analysis revealed an overrepresentation of the predicted miRNA targets involved in the critical pathway linked to tumor-promoting function such as: focal adhesion, adherens junction, apoptosis, Ras protein signal transduction, and p53 signaling pathway We observed an overlap of target genes enriched in cancer-related KEGG categories of NSCLC and small cell lung cancer (SCLC). This evidence concerns the gene TP53 and cancer.