Separate adjustments for HDL-cholesterol (OR 1.14 [1.02–1.27]), triglycerols (OR 1.12 [1.00–1.24]), glucose (OR 1.16 [1.03–1.29]), insulin resistance (OR 1.11 [1.00–1.24]), hs-CRP (OR 1.12 [1.00–1.25]) and UAE (OR 1.15 [1.04–1.28]) combined with the DESIR clinical model did not materially change the association between Prx4 and type 2 diabetes. This evidence concerns the gene PRDX4 and type 2 diabetes mellitus.