In 2011, vemurafenib, a specific inhibitor of BrafV600E (BRAF harbouring a point mutation resulting from a substitution of valine at amino-acid 600 with glutamine), and ipilimumab, a monoclonal antibody against cytotoxic T-lymphocyte associated antigen 4 (CTLA-4), have been approved for the treatment of melanoma[6]. Here, CTLA4 is linked to melanoma.