BDKRB2 and preeclampsia: Here we tested our hypothesis that disturbing the endogenous balance between the RAS and the KKS in pregnant guinea-pigs, during the period of maximal trophoblast invasion and placental development [37], by the administration of angiotensin II or Bradyzide – a potent non-peptide antagonist of the B2R [38] - would provoke a defective trophoblast invasion, fetal losses, blood pressure changes and preeclampsia-like morphological and functional alterations.