CD4 and immune system disorder: These changes indicate an immune deviation toward memory phenotype and senescence that is more marked in elderly CMV seropositive individuals.We have seen various cases of profound CD4+ T lymphocytopenia with clinical immunodeficiency in HIV negative people, all of whom showed laboratory evidence of chronic CMV and EBV infections and active replication of CMV, evidenced by positive IFI for the PP65 antigen of CMV in peripheral blood.