In regard to virus infection and lymphocytopenia or CD4+ T lymphocytopenia, a great variety of acute infections are known to produce alterations such as the cold virus, hepatitis B, hepatitis C, influenza, dengue, herpes simplex, herpes virus 6, herpes virus 7, parvovirus B19, varicella zoster, acute cytomegalovirus (CMV) and Epstein Barr virus (EBV). This evidence concerns the gene CD4 and viral infectious disease.