Thus, mutations in TDP-43 cause some familial forms of ALS andFTD, accumulations of TDP-43 area hallmark pathology of ALS/FTD and overexpression of both wild-type and familialALS-associated mutants of TDP-43all induce disease in transgenic rodents17, 24, 25, 26, 27, 28, 32. Here, TARDBP is linked to amyotrophic lateral sclerosis.