Moreover, there was significant difference in act1 mRNA in polyp tissues (1.1[0.7, 1.8]) and normal controls (0.8[0.3, 1.2])(Fig 2C, p<0.05), and act1 mRNA was significantly correlated with IL-17A mRNA in polyp tissues (Fig 2E, p<0.05). The gene discussed is TRAF3IP2; the disease is polyp.