For example, of the 8 patients with severe liver fibrosis (stages 3 and 4) and PNALT, only 2 patients had 4 ALT measurements over 12 months (over the period of 0, 3, 6, and 12 months), while 3 patients had 3 ALT measurements over 12 months, and the remaining 3 patients had only 2 ALT measurements over the 12 months period. The gene discussed is GPT; the disease is Hepatic fibrosis.