IFNG and allergic asthma: Our approach was to focus on the allergic asthma counter-regulatory IFNγ gene promoter, susceptible to epigenetic regulation following environmental exposures[16], and due to the more sensitive approach of pyrosequencing we identified cell/tissue specific methylation differences in a gene not previously reported by Stefanowicz et al. The strong correlations between CpGs -186 and -54 in CD4+ lymphocytes and weaker correlations between the same sites in buccal cells reported here also highlight the varying behavior of neighboring CpG methylation in different tissues.