ZPBP2 and asthma: In a cohort of asthmatics and non-asthmatics, Naumova et al.[23] reported lower mean methylation levels in males compared with females, as well as slight increases in methylation with age in the zona pellucida binding protein 2 (ZPBP2) promoter, a gene found in the 17q12-q21 chromosome region that has been linked to childhood onset of asthma.