There are numerous other acquired (prolonged immobilization, pregnancy, oral contraceptive pills, advanced age, obesity, cigarette use, hypertension, etc.)or genetic (protein C or S deficiency, antithrombin-III deficiency, platelet GPIIb/IIIa HPA-Ib mutation, elevated levels of Factors VII, VIII, IX, and XII, Von Willebrand disease, fibrinogen, etc.)factors that are known to cause hypercoagulation. This evidence concerns the gene SERPINC1 and thrombophilia.