Our aim in this study was to investigate gene polymorphisms of MTHFR C677T and A1298C, Factor II (G20210A), Factor V (G1691A), and PAI-1 (plasminogen activator inhibitor-1) 4G/5G that are associated with inherited hypercoagulation and TNF-α (tumor necrosis factor-alpha) 308 G > A that is associated with apoptosis of pituitary cells due to autoimmunity. This evidence concerns the gene SERPINE1 and thrombophilia.