There are numerous other acquired (prolonged immobilization, pregnancy, oral contraceptive pills, advanced age, obesity, cigarette use, hypertension, etc.)or genetic (protein C or S deficiency, antithrombin-III deficiency, platelet GPIIb/IIIa HPA-Ib mutation, elevated levels of Factors VII, VIII, IX, and XII, Von Willebrand disease, fibrinogen, etc.)factors that are known to cause hypercoagulation. This evidence concerns the gene SERPINC1 and obesity due to melanocortin 4 receptor deficiency.