TP53 and colon carcinoma: Human colon carcinoma cells of HCT-116 wild-type line (with intact copies of the p53 and Bax genes) and its sub-lines HCT-116 (Bax (−/−) and HCT-116/p53 (−/−) characterized by a knockout of Bax and p53 genes, respectively, were chosen as an experimental model.