Moreover, our study suggests that schizophrenia linked cSNPs in TM domain of NRG1 (Walss-Bass et al., 2006; Mei and Xiong, 2008) and mutations in APH1B gene (Hatzimanolis et al., 2013) may contribute to the alteration of dendritic spines density observed in schizophrenia (Lewis and Sweet, 2009; Glausier and Lewis, 2013), linking APH1B and NRG1 misprocessing firmly to this disorder. The gene discussed is APH1B; the disease is schizophrenia.