Conversely, deletion of the Aph1bc-γ-secretase complex does not affect Notch signalling but hampers Nrg1 processing and alters sensory motor gating, working memory and sensitivity to psychotropic drugs, thereby mimicking Nrg1 deficiency and various phenotypes related to schizophrenia (Coolen et al., 2005, 2006; Dejaegere et al., 2008). The gene discussed is NRG1; the disease is schizophrenia.