The EspA protein of enteropathogenic Escherichia coli (EPEC), which is an orthologue of Salmonella SseB, has been evaluated as a protective vaccine candidate in EPEC.23 In seeking to further establish the credentials of SseB as a Salmonella vaccine candidate antigen, we here set out to validate the credentials of SseB as a target of CD4 immunity in the context of Salmonella infection and determine the impact of HLA class II polymorphisms on immune recognition of immunodominant epitopes. This evidence concerns the gene CD4 and Salmonella Infections.