The prevalence of HML-2 pol, gag and env mRNA, and Gag and Env proteins in melanoma is well established.17–19,51–54 In 2002, a sequence homologous to HERV-K (HML-6) was identified in melanoma patients (HERV-K-MEL).31 HERV-K-MEL, which produces an antigen spliced from a defective noncoding env-like ORF, was reported in cutaneous and ocular melanomas, and nevi. Here, ERVW-1 is linked to melanoma.