Studies by Wang et al. [45] demonstrated that in a non-small cell lung carcinoma cell line, an ovarian cancer cell line, and a colon adenocarcinoma cell line, that the acridine derivatives 9AA, amsacrine, quinacrine and acridine orange, stabilized p53 and induced p53 dependent apoptosis. This evidence concerns the gene TP53 and colon adenocarcinoma.