Using the multivariate analysis to stratify the patients according to stage, uPAR-positive macrophages in tumor core and level of uPAR(I) in plasma resulted in a remarkable separation, the HRs for a patient with uPAR-positive/negative and uPAR(I) equal to the first and third quartile for stages II and III are shown (Fig.3). The gene discussed is PLAUR; the disease is neoplasm.