Resveratrol improves cardiac dysfunction and remodelling and attenuates cardiomyocyte apoptosis and oxidative stress injury in diabetic mice, associated with the regulation of autophagic flux through SIRT1/FOXO1/Rab7 axis, which suggests a therapeutic strategy for diabetic cardiomyopathy. The gene discussed is SIRT1; the disease is diabetic cardiomyopathy.