In summary, bovine parthenogenetic oocyte extract treatment induces an activating epigenetic state at the promoters of the tumour suppressor genes RUNX3 and CDH1, and a suppressing epigenetic state at the promoters of the oncogenic pluripotency gene SOX2. This epigenetic remodelling effect leads to activation of RUNX3 and CDH1 expression, and repression of SOX2 expression. This evidence concerns the gene RUNX3 and neoplasm.