SOX2 and neoplasm: In summary, bovine parthenogenetic oocyte extract treatment induces an activating epigenetic state at the promoters of the tumour suppressor genes RUNX3 and CDH1, and a suppressing epigenetic state at the promoters of the oncogenic pluripotency gene SOX2. This epigenetic remodelling effect leads to activation of RUNX3 and CDH1 expression, and repression of SOX2 expression.