RORA and autism: Gene expression levels of an autism-associated gene, retinoic acid-related orphan receptor-α (RORA), are lowered by testosterone and elevated by estradiol, and transcriptionally regulates several autism-associated genes including CYP19A1, thus affected aromatase levels.46,47 Although we were unable to test estradiol in the current study owing to lack of an automated liquid chromatography tandem mass spectrometry assay, we intend to investigate this in future work.