In this study we analyzed the effects of the stilbene RSV and the synthetic fluorinated dialkylaminostilbene ((E)-4-(2, 6-Difluorostyryl)-N, N-dimethylaniline or FIDAS-3 [19] on AR- and ARΔLBD in prostate cancer cells in vitro and in vivo. This evidence concerns the gene AR and Familial prostate cancer.